Temporal model for central sensitization: A hypothesis for mechanism and treatment using systemic manual therapy, a focused review.

ABSTRACT: The purpose of this focused review is to develop a consolidated hypothesis as to the causes and mechanisms of central sensitization and a related model for a treatment approach using Systemic Manual Therapy (SMT). The key to understanding central sensitization is a firm grasp on structure and function of the Locus-coeruleus noradrenaline system (LC-NA). This system uses an elaborate switching mechanism to control the level and rate of activation of multiple systems. This review evaluates the mechanisms and temporal relationships behind four components: salient stimuli, threat coding, aberrant afferent input, and oxidative stress. The five-stage temporal model for central sensitization includes phasic activation of the LC-NA system, salient stimuli, threat coding of salient stimuli, central

SUBMITTER: Halili A 

PROVIDER: S-EPMC9772546 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature