Immunological profiles of human oligodendrogliomas define two distinct molecular subtypes.

ABSTRACT:

Background

Human oligodendroglioma presents as a heterogeneous disease, primarily characterized by the isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion. Therapy development for this tumor is hindered by incomplete knowledge of somatic driving alterations and suboptimal disease classification. We herein aim to identify intrinsic molecular subtypes through integrated analysis of transcriptome, genome and methylome.

Methods

137 oligodendroglioma patients from the Cancer Genome Atlas (TCGA) dataset were collected for unsupervised clustering analysis of immune gene expression profiles and comparative analysis of genome and methylome. Two independent datasets containing 218 patients were used for validation.

Findings

We identified and independently validated t

SUBMITTER: Wu F 

PROVIDER: S-EPMC9772571 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature