Ontology highlight
ABSTRACT:
SUBMITTER: Freitas de Freitas T
PROVIDER: S-EPMC9772590 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Freitas de Freitas Talita T Roth Candida Deves CD Abbadi Bruno Lopes BL Hopf Fernanda Souza Macchi FSM Perelló Marcia Alberton MA de Matos Czeczot Alexia A de Souza Eduardo Vieira EV Borsoi Ana Flávia AF Machado Pablo P Bizarro Cristiano Valim CV Basso Luiz Augusto LA Timmers Luis Fernando Saraiva Macedo LFSM
Journal of computer-aided molecular design 20221222 3
Tuberculosis (TB) is one of the main causes of death from a single pathological agent, Mycobacterium tuberculosis (Mtb). In addition, the emergence of drug-resistant TB strains has exacerbated even further the treatment outcome of TB patients. It is thus needed the search for new therapeutic strategies to improve the current treatment and to circumvent the resistance mechanisms of Mtb. The shikimate kinase (SK) is the fifth enzyme of the shikimate pathway, which is essential for the survival of ...[more]