The role of circadian clock in astrocytes: From cellular functions to ischemic stroke therapeutic targets.

ABSTRACT: Accumulating evidence suggests that astrocytes, the abundant cell type in the central nervous system (CNS), play a critical role in maintaining the immune response after cerebral infarction, regulating the blood-brain barrier (BBB), providing nutrients to the neurons, and reuptake of glutamate. The circadian clock is an endogenous timing system that controls and optimizes biological processes. The central circadian clock and the peripheral clock are consistent, controlled by various circadian components, and participate in the pathophysiological process of astrocytes. Existing evidence shows that circadian rhythm controls the regulation of inflammatory responses by astrocytes in ischemic stroke (IS), regulates the repair of the BBB, and plays an essential role in a series of pathological p

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9772621 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature