Activated B cells suppress T-cell function through metabolic competition.

ABSTRACT:

Background

B cells play a pivotal role in regulating the immune response. The induction of B cell-mediated immunosuppressive function requires B cell activating signals. However, the mechanisms by which activated B cells mediate T-cell suppression are not fully understood.

Methods

We investigated the potential contribution of metabolic activity of activated B cells to T-cell suppression by performing in vitro experiments and by analyzing clinical samples using mass cytometry and single-cell RNA sequencing.

Results

Here we show that following activation, B cells acquire an immunoregulatory phenotype and promote T-cell suppression by metabolic competition. Activated B cells induced hypoxia in T cells in a cell-cell contact dependent manner by consuming more oxygen via a

SUBMITTER: Imahashi N 

PROVIDER: S-EPMC9772692 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature