Systemic cellular viroimmunotherapy for canine high-grade gliomas.

ABSTRACT:

Background

Oncolytic viruses constitute a growing field of interest, both in human and veterinary oncology, given that they are particularly helpful for treating non-surgical tumors and disseminated cancer, such as high-grade gliomas. Companion dogs present malignant gliomas with biological, genetic, phenotypic, immunological, and clinical similarities to human gliomas. These features favor comparative approaches, leading to the treatment of canine oncological patients to achieve translational applications to the human clinic. The systemic administration of oncolytic viruses presents a challenge due to their limitations in effectively targeting tumors and metastases. Therefore, the aim of this study is to evaluate the safety and antitumor activity of a virotherapy used in spontaneo

SUBMITTER: Cloquell A 

PROVIDER: S-EPMC9772696 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature