Pupillary dynamics of mice performing a Pavlovian delay conditioning task reflect reward-predictive signals.

ABSTRACT: Pupils can signify various internal processes and states, such as attention, arousal, and working memory. Changes in pupil size have been associated with learning speed, prediction of future events, and deviations from the prediction in human studies. However, the detailed relationships between pupil size changes and prediction are unclear. We explored pupil size dynamics in mice performing a Pavlovian delay conditioning task. A head-fixed experimental setup combined with deep-learning-based image analysis enabled us to reduce spontaneous locomotor activity and to track the precise dynamics of pupil size of behaving mice. By setting up two experimental groups, one for which mice were able to predict reward in the Pavlovian delay conditioning task and the other for which mice were not, we d

SUBMITTER: Yamada K 

PROVIDER: S-EPMC9772849 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature