Metabolite patterns associated with individual response to supervised exercise therapy in patients with intermittent claudication.

ABSTRACT:

Objective

Supervised exercise therapy (SET) is the first line treatment for intermittent claudication owing to peripheral arterial disease. Despite multiple randomized controlled trials proving the efficacy of SET, there are large differences in individual patient's responses. We used plasma metabolomics to identify potential metabolic influences on the individual response to SET.

Methods

Primary metabolites, complex lipids, and lipid mediators were measured on plasma samples taken at before and after Gardner graded treadmill walking tests that were administered before and after 12 weeks of SET. We used an ensemble modeling approach to identify metabolites or changes in metabolites at specific time points that associated with interindividual variability in the functional res

SUBMITTER: Bellomo TR 

PROVIDER: S-EPMC9772856 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature