A method of characterising the complex anatomy of vascular occlusions and 3D printing biomimetic analogues.

ABSTRACT: Chronic total occlusions (CTOs) occur in approximately 40% of individuals with symptomatic peripheral arterial disease and are indicative of critical limb ischaemia. Currently, few medical devices can effectively treat CTOs long-term, with amputation often required. This is due to a lack of knowledge of CTO anatomy, making device design and testing difficult. This study is a proof-of-concept study, which aimed to develop a workflow for further characterising the complex multi-material anatomy of CTOs and creating 3D models of CTO components, which may be useful in producing a vascular CTO biomimetic for device testing. Here, we establish such a workflow using samples of atheromatous plaques. We focus on a high-resolution, non-destructive microcomputed tomography (μCT) technique which enabl

SUBMITTER: O'Reilly M 

PROVIDER: S-EPMC9773163 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature