MRI-based strain measurements reflect morphological changes following myocardial infarction: A study on the UK Biobank cohort.

ABSTRACT: In a porcine experimental model of myocardial infarction, a localised, layer-specific, circumferential left ventricular strain metric has been shown to indicate chronic changes in ventricular function post-infarction more strongly than ejection fraction. This novel strain metric might therefore provide useful prognostic information clinically. In this study, existing clinical volume indices, global strains, and the novel, layer-specific strain were calculated for a large human cohort to assess variations in ventricular function and morphology with age, sex, and health status. Imaging and health data from the UK Biobank were obtained, including healthy volunteers and those with a history of cardiovascular illness. In total, 710 individuals were analysed and stratified by age, sex and health

SUBMITTER: Mansell DS 

PROVIDER: S-EPMC9773168 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature