Systematic literature review and meta-analysis of clinical outcomes and prognostic factors for melanoma brain metastases.

ABSTRACT:

Background

More than 60% of all stage IV melanoma patients develop brain metastases, while melanoma brain metastases (MBM) is historically difficult to treat with poor prognosis.

Objectives

To summarize clinical outcomes and prognostic factors in MBM patients.

Methods

A systematic review with meta-analysis was conducted, and a literature search for relevant studies was performed on November 1, 2020. Weighted average of median overall survival (OS) was calculated by treatments. The random-effects model in conducting meta-analyses was applied.

Results

A total of 41 observational studies and 12 clinical trials with our clinical outcomes of interest, and 31 observational studies addressing prognostic factors were selected. The most common treatments for MBM were im

SUBMITTER: Tan XL 

PROVIDER: S-EPMC9773194 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature