Combination of antiplatelet and anticoagulant therapy, component network meta-analysis of randomized controlled trials

ABSTRACT:

Background

Despite numerous randomized clinical trials (RCT), data regarding the efficacy of antiplatelet and anticoagulant combinations are still conflicting. We aimed to analyze treatment options tested in various fields of cardiovascular prevention, regarding their efficacy and bleeding risk.

Methods

Systematic searches of electronic databases were conducted until June 2022. A component network meta-analysis was performed in R. Risk estimates across trials were pooled using random-effects model selecting risk ratio (RR) with 95% confidence intervals (95% CIs) as summary statistics. The primary endpoint of interest was the rate of major cardiac adverse events (MACE). Major bleeding events were assessed as main safety endpoint. Secondary outcomes included cardiovascular-

SUBMITTER:  

PROVIDER: S-EPMC9773199 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature