Dataset Information

Research on the Dynamic Response Properties of Nonlethal Projectiles for Injury Risk Assessment.

ABSTRACT: Based on the models already on the market, we have manufactured six types of nonlethal projectiles. We have made convex heads out of polyurethane foam (PUR) filled with mineral fillers like alumina (Al₂O₃) and montmorillonite (MMT). We chose a suitable holder for nonlethal projectiles. Also, we made a custom industrial model and used CAD modeling in SolidWorks to simulate the deformation of the nonlethal projectiles. The polymeric nonlethal projectile holders were then 3D-printed. We performed a dynamic mechanical analysis (DMA) and discussed the results. Likewise, we conducted ballistic impact experiments on nonlethal projectiles (XM1006) and nonlethal projectiles manufactured that were evaluated using a rigid wall and a pneumatic launcher. Furthermore, we looked at cell structure, the spread of the mean pore diameter, and the particle size distributions of the mineral fillers using scanning electron microscopy (SEM). We evaluated and discussed injury risks from nonlethal impacts. Data on nonlethal projectile lethality and safe impact speed are collected. This study explains how lab studies and real-world practice coexist through nonlethal projectile properties.

SUBMITTER: Boumdouha N

PROVIDER: S-EPMC9773345 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Research on the Dynamic Response Properties of Nonlethal Projectiles for Injury Risk Assessment.

Boumdouha Noureddine N Duchet-Rumeau Jannick J Gerard Jean-François JF Tria Djalel Eddine DE Oukara Amar A

ACS omega 20221208 50

Based on the models already on the market, we have manufactured six types of nonlethal projectiles. We have made convex heads out of polyurethane foam (PUR) filled with mineral fillers like alumina (Al<sub>2</sub>O<sub>3</sub>) and montmorillonite (MMT). We chose a suitable holder for nonlethal projectiles. Also, we made a custom industrial model and used CAD modeling in SolidWorks to simulate the deformation of the nonlethal projectiles. The polymeric nonlethal projectile holders were then 3D-p ...[more]

PMID: 36570218

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Project description:BACKGROUND:To develop an individually-tailored dynamic risk assessment model following a multistep, multifactorial process of the Correa's gastric cancer model. METHODS:First, we estimated the state-to-state transition rates following Correa's five-step carcinogenic model and assessed the effect of risk factors, including Helicobacter pylori infection, history of upper gastrointestinal disease, lifestyle, and dietary habits, on the step-by-step transition rates using data from a high-risk population in Matsu Islands, Taiwan. Second, we incorporated information on the gastric cancer carcinogenesis affected by genomic risk factors (including inherited susceptibility and irreversible genomic changes) based on literature to generate a genetic and epigenetic risk assessment model by using a simulated cohort identical to the Matsu population. The combination of conventional and genomic risk factors enables us to develop the personalized transition risk scores and composite scores. RESULTS:The state-by-state transition rates per year were 0.0053, 0.7523, 0.1750, and 0.0121 per year from normal mucosa to chronic active gastritis, chronic active gastritis to atrophic gastritis, atrophic gastritis to intestinal metaplasia, and intestinal metaplasia to gastric cancer, respectively. Compared with the median risk group, the most risky decile had a 5.22-fold risk of developing gastric cancer, and the least risky decile around one-twelfth of the risk. The median 10-year risk for gastric cancer incidence was 0.77%. The median lifetime risk for gastric cancer incidence was 5.43%. By decile, the 10-year risk ranged from 0.06 to 4.04% and the lifetime risk ranged from 0.42 to 21.04%. CONCLUSIONS:We demonstrate how to develop a personalized dynamic risk assessment model with the underpinning of Correa's cascade to stratify the population according to their risk for progression to gastric cancer. Such a risk assessment model not only facilitates the development of an individually-tailored preventive strategy with treatment for H. pylori infection and endoscopic screening but also provides short-term and long-term indicators to evaluate the program effectiveness.

Dataset Information

Research on the Dynamic Response Properties of Nonlethal Projectiles for Injury Risk Assessment.

Publications

Research on the Dynamic Response Properties of Nonlethal Projectiles for Injury Risk Assessment.

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