Gut microbiota profiling variated during colorectal cancer development in mouse.

ABSTRACT:

Background

The imbalance of intestinal flora may promote the occurrence and development of colorectal cancer, changes of the intestinal flora during the development of colorectal cancer and the mechanism that promotes the colorectal cancer were discovered in this study. Deep sequencing of the microbial 16 s ribosomal RNA gene was used to investigate alterations in feces samples of mice at the early inflammation stage and fully developed stage of colorectal cancer.

Results

According to PCoA analysis and ANOSIM test, we found the intestinal flora had significantly changed in mice with colorectal inflammation or colorectal cancer compared with healthy mice (p < 0.05). Using correlation analysis, we found that Muribaculaceae and Bacteroidaceae had strong excluding interactions.

SUBMITTER: Liu J 

PROVIDER: S-EPMC9773433 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature