UGDR: a generic pipeline to detect recombined regions in polyploid and complex hybrid yeast genomes.

ABSTRACT: In eukaryotes, homologous recombination between the parental genomes frequently occurs during the evolutionary conserved process of meiosis, generating the genetic diversity transmitted by the gametes. The genome-wide determination of the frequency and location of the recombination events can now be efficiently performed by genotyping the offspring's polymorphic markers. However, genotyping recombination in complex hybrid genomes with existing methods remains challenging because of their strain and ploidy specificity and the degree of diversity and complexity of the parental genomes, especially in [Formula: see text] polyploids. We present UGDR, a pipeline to genotype the polymorphisms of complex hybrid yeast genomes. It is based on optimal mapping strategies of NGS reads, comparative anal

SUBMITTER: Bedrat A 

PROVIDER: S-EPMC9773435 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature