Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice.

ABSTRACT:

Background

Obesity rates are increasing worldwide. Obesity leads to many complications, including predisposing individuals to the development of cognitive impairment as they age. Immune dysregulation, including inflammaging (e.g., increased circulating cytokines) and immunosenescence (declining immune system function), commonly occur in obesity and aging and may impact cognitive impairment. As such, immune system changes across the lifespan may impact the effects of obesity on neuroinflammation and associated cognitive impairment. However, the role of age in obesity-induced neuroinflammation and cognitive impairment is unclear. To further define this putative relationship, the current study examined metabolic and inflammatory profiles, along with cognitive changes using a high-fat

SUBMITTER: Henn RE 

PROVIDER: S-EPMC9773607 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature