Markers of immune dysregulation in response to the ageing gut: insights from aged murine gut microbiota transplants.

ABSTRACT:

Background

Perturbations in the composition and diversity of the gut microbiota are accompanied by a decline in immune homeostasis during ageing, characterized by chronic low-grade inflammation and enhanced innate immunity. Genetic insights into the interaction between age-related alterations in the gut microbiota and immune function remain largely unexplored.

Methods

We investigated publicly available transcriptomic gut profiles of young germ-free mouse hosts transplanted with old donor gut microbiota to identify immune-associated differentially expressed genes (DEGs). Literature screening of the Gene Expression Omnibus and PubMed identified one murine (Mus musculus) gene expression dataset (GSE130026) that included small intestine tissues from young (5-6 weeks old) germ-fr

SUBMITTER: Giannos P 

PROVIDER: S-EPMC9773626 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature