Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β-amyloid peptide (25-35)-induced memory impairment in mice.

ABSTRACT:

Aim

We previously reported that oxytocin, a peptide hormone, can reverse the β-amyloid peptide (25-35) (Aβ_25-35 )-induced impairments of the murine hippocampal synaptic plasticity. In this study, we examined the effects of oxytocin on the Aβ_25-35 -induced impairment of cognitive behavior in murine in order to investigate the potential of oxytocin as a clinical treatment tool for Alzheimer's disease (AD).

Methods

The Y-maze and Morris water maze (MWM) tests were performed. Since the intracerebroventricular (ICV) administration is both invasive and impractical, we further utilized intranasal (IN) delivery to the brain. For this purpose, we prepared an oxytocin derivative containing cell-penetrating peptides and a penetration accelerating sequence, which w

SUBMITTER: Takahashi J 

PROVIDER: S-EPMC9773650 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature