Neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure.

ABSTRACT:

Aims

Given the various effects of sacubitril/valsartan in heart failure, a deeper understanding of atrial natriuretic peptide (ANP) actions is warranted. Natriuresis is a fundamental action of ANP in acute heart failure (AHF), whereas the diuretic effect of ANP is different in each patient according to the diversity of renal response to ANP, which is affected by baseline plasma ANP status and deficiency of circulating ANP. Meanwhile, associations between other neuroendocrine hormones and the diuretic response to ANP are unclear. This study investigated the impact of pivotal neuroendocrine hormones on the diuretic effects of exogenous ANP, carperitide.

Methods and results

Plasma ANP, renin, aldosterone, and vasopressin levels and the diuretic effect of 0.0125 μg/kg/min of car

SUBMITTER: Matsumoto S 

PROVIDER: S-EPMC9773655 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature