Association between trimethylamine N-oxide and prognosis of patients with acute myocardial infarction and heart failure.

ABSTRACT:

Aims

This study aimed to investigate the association between trimethylamine N-oxide (TMAO) and the prognosis and association between high-sensitivity C-reactive protein (hsCRP) and TMAO-associated cardiovascular risk in patients with acute myocardial infarction (AMI) complicated by heart failure (HF).

Methods and results

A total of 985 patients presenting with AMI and HF were consecutively enrolled at the Fuwai Hospital between March 2017 and January 2020. Patients were stratified into groups according to tertiles of TMAO levels and the median hsCRP levels. The primary endpoint was major adverse cardiac events (MACE), including all-cause death, recurrence of myocardial infarction, and rehospitalization due to HF. During a median follow-up of 716 days, 138 (14.0%) patients ex

SUBMITTER: Li N 

PROVIDER: S-EPMC9773708 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature