Prescribed opioid use is associated with adverse cardiovascular outcomes in community-dwelling older persons.

ABSTRACT:

Aims

Prescribed opioids are commonly used in the older community-dwelling population for the treatment of chronic pain. Although the harmful effects of opioid abuse and overdose are well understood, little is known about the long-term cardiovascular (CV) effects of prescribed opioids. The aim of this study was to investigate the CV effects associated with prescribed opioid use.

Methods and results

A post hoc analysis of participants in the Aspirin in Reducing Events in the Elderly (ASPREE) trial was conducted. Participants in the ASPREE trial included community-dwelling older adults without a prior history of CV disease (CVD). Prescribed opioid use was defined as opioid use at baseline and/or at the first annual visit (AV1). Cox proportional hazards regression was used to ca

SUBMITTER: Liew SM 

PROVIDER: S-EPMC9773735 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature