An echo score raises the suspicion of cardiac amyloidosis in Chinese with heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Transthyretin cardiac amyloidosis (ATTR-CA) has been realized as an important cause of heart failure with preserved ejection fraction (HFpEF). We aim to provide insights into its prevalence in Chinese HFpEF patients, which is not known to date, using increased wall thickness (IWT) score by echocardiography.

Methods

Consecutive patients with HFpEF (EF ≥ 40%) and IWT (≥12 mm) were prospectively screened. Echocardiography was performed, and the IWT score incorporated relative wall thickness, E/e' ratio, longitudinal strains, and tricuspid annular plane systolic excursion, and septal apical-to-base ratio was calculated. ATTR-CA was defined as score ≥8 in the absence of serum and urine free light chain.

Results

Six hundred twenty-four HFpEF patients from January 2019

SUBMITTER: Yang H 

PROVIDER: S-EPMC9773758 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature