Elevated plasma WIF-1 levels are associated with worse prognosis in heart failure with pulmonary hypertension.

ABSTRACT:

Aims

Heart failure (HF) is a progressive condition that is becoming more prevalent in the ageing population. Pulmonary hypertension is a common complicating factor in HF and negatively impacts survival. Plasma biomarkers are a potential method for determining the prognosis of patients with left heart failure with pulmonary hypertension (LHF-PH). We aimed to analyse the prognostic capability of 33 proteins related to, among other pathways, inflammation, coagulation, and Wnt signalling in LHF-PH.

Methods

Plasma levels of 33 proteins were analysed using proximity extension assay from the plasma of 20 controls and 67 LHF-PH patients, whereof 19 underwent heart transplantation (HT). Haemodynamics in the patients were assessed using right heart catheterization.

Results

Elev

SUBMITTER: Kania K 

PROVIDER: S-EPMC9773778 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature