Association of immune cell subsets with incident heart failure in two population-based cohorts.

ABSTRACT:

Aims

Circulating inflammatory markers are associated with incident heart failure (HF), but prospective data on associations of immune cell subsets with incident HF are lacking. We determined the associations of immune cell subsets with incident HF as well as HF subtypes [with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF)].

Methods and results

Peripheral blood immune cell subsets were measured in adults from the Multi-Ethnic Study of Atherosclerosis (MESA) and Cardiovascular Health Study (CHS). Cox proportional hazard models adjusted for demographics, HF risk factors, and cytomegalovirus serostatus were used to evaluate the association of the immune cell subsets with incident HF. The average age of the MESA cohort at the time of immune cell measure

SUBMITTER: Sinha A 

PROVIDER: S-EPMC9773780 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature