Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve.

ABSTRACT:

Introduction

Several lifestyle factors promote protection against Alzheimer's disease (AD) throughout a person's lifespan. Although such protective effects have been described for occupational cognitive requirements (OCR) in midlife, it is currently unknown whether they are conveyed by brain maintenance (BM), brain reserve (BR), or cognitive reserve (CR) or a combination of them.

Methods

We systematically derived hypotheses for these resilience concepts and tested them in the population-based AgeCoDe cohort and memory clinic-based AD high-risk DELCODE study. The OCR score (OCRS) was measured using job activities based on the O*NET occupational classification system. Four sets of analyses were conducted: (1) the interaction of OCR and APOE-ε4 with regard to cognitive decline

SUBMITTER: Kleineidam L 

PROVIDER: S-EPMC9773841 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature