Ontology highlight
ABSTRACT:
SUBMITTER: Farrell KB
PROVIDER: S-EPMC9773925 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Farrell Kristen B KB Zinnen Shawn S Thamm Douglas H DH Karpeisky Alexander A
Bioconjugate chemistry 20211115 12
Patients with cancer-induced bone disease, including primary bone cancers such as osteosarcoma (OS) and metastases from other tissues of origin, present a high unmet medical need. We present a potential therapeutic approach built upon a proven bone-targeting bisphosphonate conjugate platform with the known synergies of gemcitabine (GEM) and docetaxel (DTX). The synthesis of rationally designed GEM-IB, the conjugate of GEM-5'-phosphate with ibandronate (IB), is presented. GEM-IB as a single agent ...[more]