Development and validation of diagnostic models for immunoglobulin A nephropathy based on gut microbes.

ABSTRACT:

Background

Immunoglobulin A nephropathy (IgAN) is a highly prevalent glomerular disease. The diagnosis potential of the gut microbiome in IgAN has not been fully evaluated. Gut microbiota, serum metabolites, and clinical phenotype help to further deepen the understanding of IgAN.

Patients and methods

Cohort studies were conducted in healthy controls (HC), patients of IgA nephropathy (IgAN) and non-IgA nephropathy (n_IgAN). We used 16S rRNA to measure bacterial flora and non-targeted analysis methods to measure metabolomics; we then compared the differences in the gut microbiota between each group. The random forest method was used to explore the non-invasive diagnostic value of the gut microbiome in IgAN. We also compared serum metabolites and analyzed their correlation with

SUBMITTER: Dong Y 

PROVIDER: S-EPMC9774022 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature