Local-Scale phylodynamics reveal differential community impact of SARS-CoV-2 in metropolitan US county.

ABSTRACT: SARS-CoV-2 transmission is largely driven by heterogeneous dynamics at a local scale, leaving local health departments to design interventions with limited information. We analyzed SARS-CoV-2 genomes sampled between February 2020 and March 2022 jointly with epidemiological and cell phone mobility data to investigate fine scale spatiotemporal SARS-CoV-2 transmission dynamics in King County, Washington, a diverse, metropolitan US county. We applied an approximate structured coalescent approach to model transmission within and between North King County and South King County alongside the rate of outside introductions into the county. Our phylodynamic analyses reveal that following stay-at-home orders, the epidemic trajectories of North and South King County began to diverge. We find that Sout

SUBMITTER: Paredes MI 

PROVIDER: S-EPMC9774227 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature