Neuronal Oxidative Stress Promotes α-Synuclein Aggregation In Vivo.

ABSTRACT: Both genetic and environmental factors increase risk for Parkinson's disease. Many of the known genetic factors influence α-synuclein aggregation or degradation, whereas most of the identified environmental factors produce oxidative stress. Studies using in vitro approaches have identified mechanisms by which oxidative stress can accelerate the formation of α-synuclein aggregates, but there is a paucity of evidence supporting the importance of these processes over extended time periods in brain. To assess this issue, we evaluated α-synuclein aggregates in brains of three transgenic mouse strains: hSyn mice, which overexpress human α-synuclein in neurons and spontaneously develop α-synuclein aggregates; EAAT3^-/- mice, which exhibit a neuron-specific impairment in cysteine uptake

SUBMITTER: Won SJ 

PROVIDER: S-EPMC9774295 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature