Preparation and Characterization of Ginger Peel Polysaccharide-Zn (II) Complexes and Evaluation of Anti-Inflammatory Activity.

ABSTRACT: The present study aimed to explore the improvement of the bioactivity of ginger peel polysaccharides (GPs) by the modification of zinc after structural characterization. The obtained GP-Zn (II) complexes consisted dominantly of glucose and galactose in a mass proportion of 95.10:2.10, with a molecular weight of 4.90 × 10⁵ Da and a Zn content of 21.17 mg/g. The chelation of GPs and Zn (II) was mainly involved in the O-H of hydroxyl groups, and this interaction reduced the crystallinity and decreased the asymmetry of GPs, with a slight effect on the thermal stability. The administration of GPs and their Zn (II) complexes effectively alleviated CuSO₄-induced inflammatory response in zebrafish (Tg: zlyz-EGFP) via down-regulating the mRNA expression le

SUBMITTER: Li W 

PROVIDER: S-EPMC9774354 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature