The Anti-Virulence Effect of <i>Vismia guianensis</i> against <i>Candida albicans</i> and <i>Candida glabrata</i>.

ABSTRACT: In folk medicine, Vismia guianensis is used to treat skin diseases and mycoses in the Amazon region. We evaluated the anti-Candida activity of the hydroalcoholic extract from the leaves of Vismia guianensis (EHVG). HPLC-PDA and FIA-ESI-IT-MSⁿ were used to chemically characterize EHVG. The anti-Candida activity was determined in vitro by the minimum inhibitory concentrations (MIC) against Candida glabrata (ATCC-2001); Candida albicans (ATCC-90028, ATCC-14053, and ATCC-SC5314), and C. albicans clinical isolates. EHVG effects on adhesion, growth, and biofilm formation were also determined. Molecular docking was used to predict targets for EHVG compounds. The main compounds identified included anthraquinone, vismione D, kaempferol, qu

SUBMITTER: Motta EP 

PROVIDER: S-EPMC9774440 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature