Gold(III) Complexes Activity against Multidrug-Resistant Bacteria of Veterinary Significance.

ABSTRACT: The emergence and spread of multidrug-resistant bacteria are a global concern. The lack of new antibiotics in the pipeline points to the need for developing new strategies. In this sense, gold(III) complexes (G3Cs) could be a promising alternative due to their recently described antibacterial activity. The aim of this study was to evaluate the antimicrobial activity of G3Cs alone and in combination with colistin against pathogenic bacteria from veterinary sources. Minimal inhibitory concentration (MIC) values were determined by broth microdilution and compared with clinically relevant antibiotics. Antibiofilm activity was determined by crystal violet staining. Combinations of selected G3Cs with colistin and cytotoxicity in commercial human cell lines were evaluated. Four and seven G3Cs sho

SUBMITTER: Ratia C 

PROVIDER: S-EPMC9774617 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature