Inconsistent Detection of Sites of Metastatic Non-Clear Cell Renal Cell Carcinoma with PSMA-Targeted [¹⁸F]DCFPyL PET/CT.

ABSTRACT:

Purpose

To investigate the utility of prostate-specific membrane antigen (PSMA)-targeted [¹⁸F]DCFPyL positron emission tomography (PET)/X-ray computed tomography (CT) imaging for the detection of sites of disease in patients with metastatic non-clear cell renal cell carcinoma (RCC).

Procedures

Eight patients with metastatic non-clear cell RCC underwent imaging with PSMA-targeted [¹⁸F]DCFPyL PET/CT. Imaged RCC histologic subtypes included papillary RCC (n = 3), chromophobe RCC (n = 2), unclassified RCC (n = 2), and Xp11 translocation RCC (n = 1). Using comparison to conventional CT and/or magnetic resonance imaging as reference, two radiologists with expertise in nuclear medicine identified putative sites of disease on [¹⁸F]DCFPyL PET/CT and c

SUBMITTER: Yin Y 

PROVIDER: S-EPMC9774683 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature