Short-Term Grape Consumption Diminishes UV-Induced Skin Erythema.

ABSTRACT: Over three million Americans are affected by skin cancer each year, largely as a result of exposure to sunlight. The purpose of this study was to determine the potential of grape consumption to modulate UV-induced skin erythema. With 29 human volunteers, we report that nine demonstrated greater resistance to UV irradiation of the skin after consuming the equivalent of three servings of grapes per day for two weeks. We further explored any potential relationship to the gut-skin axis. Alpha- and beta-diversity of the gut microbiome were not altered, but grape consumption modulated microbiota abundance, enzyme levels, and KEGG pathways. Striking differences in the microbiome and metabolome were discerned when comparing the nine individuals showing greater UV resistance with the 20 non-respond

SUBMITTER: Pezzuto JM 

PROVIDER: S-EPMC9774720 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature