Variability of Mycobacterium avium Complex Isolates Drug Susceptibility Testing by Broth Microdilution.

ABSTRACT: Non-tuberculous mycobacteria are widely distributed in environments and are capable of infecting humans, particularly those with a compromised immune system. The most prevalent species that cause nontuberculous mycobacterial lung diseases are slow-growing bacteria from the Mycobacterium avium complex (MAC), mainly M. avium or M. intracellulare. The key treatment of MAC infections includes macrolides, ethambutol, and rifampicin; however, the therapy outcomes are unsatisfactory. Phenotypic drug susceptibility testing is a conditional recommendation prior to treatment, and critical concentrations for clarithromycin, amikacin, moxifloxacin, and linezolid have been established. In this review, data from studies on the determination of MIC of clinical isolates using the broth microdilution metho

SUBMITTER: Zimenkov D 

PROVIDER: S-EPMC9774755 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature