Cyanidin Alleviated CCl₄-Induced Acute Liver Injury by Regulating the Nrf2 and NF-κB Signaling Pathways.

ABSTRACT: Acute liver injury has multiple causes and can result in liver failure. In this study, we evaluated the hepatoprotective ability of cyanidin (Cy) and investigated its associated mechanisms. Cy administration significantly and dose-dependently ameliorated acute liver injury induced by carbon tetrachloride (CCl₄). High-dose Cy showed effects comparable to those achieved by the positive control (silymarin). Severe oxidative stress and inflammatory responses in the liver tissue induced by CCl₄ were significantly mitigated by Cy supplementation. The total antioxidant capacity and the activity of superoxide dismutase, catalase, and glutathione peroxidase were increased and the content of malondialdehyde, lipid peroxide, tumor necrosis factor α, interleukin-1β, and interleuk

SUBMITTER: Wang B 

PROVIDER: S-EPMC9774769 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature