Sex Differences in the Behavioural Aspects of the Cuprizone-Induced Demyelination Model in Mice.

ABSTRACT: Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis. However, despite significant demyelination, behavioural deficits may be subtle or have mixed results depending on the paradigm used. Furthermore, the sex differences within the model are not well understood. In the current study, we have sought to understand the behavioural deficits associated with the cuprizone-induced demyelination model in both male and female C57BL/6J mice. Using Black gold II stain, we found that cuprizone administration over 6 weeks caused significant demyelination in the corpus callosum that was consistent across both sexes. Cuprizone administration c

SUBMITTER: Paton KF 

PROVIDER: S-EPMC9775311 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature