Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis.

ABSTRACT: Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA. We aimed to identify novel plasma biomarkers or potential therapeutic targets for AAA using a high-throughput protein array-based method. Proteomics expression profiles were investigated in plasma from AAA patients and healthy controls (HC) using 440-cytokine protein array analysis. Several promising biomarkers were further validated in independent cohorts using enzyme-linked immunosorbent assay (ELISA). Thirty-nine differentially expressed plasma proteins were identified between AAA and HC. Legumain (LGMN) was significantly higher in AAA patients and was validated in another large cohort. Addi

SUBMITTER: Wu J 

PROVIDER: S-EPMC9775419 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature