Xenobiotic-Metabolizing Enzymes in Trematodes.

ABSTRACT: Trematode infections occur worldwide causing considerable deterioration of human health and placing a substantial financial burden on the livestock industry. The hundreds of millions of people afflicted with trematode infections rely entirely on only two drugs (praziquantel and triclabendazole) for treatment. An understanding of anthelmintic biotransformation pathways in parasites should clarify factors that can modulate therapeutic potency of anthelmintics currently in use and may lead to the discovery of synergistic compounds for combination treatments. Despite the pronounced epidemiological significance of trematodes, there is still no adequate understanding of the functionality of their metabolic systems, including xenobiotic-metabolizing enzymes. The review is focused on the structure

SUBMITTER: Mordvinov V 

PROVIDER: S-EPMC9775572 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature