Win and Loss Responses in the Monetary Incentive Delay Task Mediate the Link between Depression and Problem Drinking.

ABSTRACT: Depression and alcohol misuse, frequently comorbid, are associated with altered reward processing. However, no study has examined whether and how the neural markers of reward processing are shared between depression and alcohol misuse. We studied 43 otherwise-healthy drinking adults in a monetary incentive delay task (MIDT) during fMRI. All participants were evaluated with the Alcohol Use Disorders Identification Test (AUDIT) and Beck's Depression Inventory (BDI-II) to assess the severity of drinking and depression. We performed whole brain regressions against each AUDIT and BDI-II score to investigate the neural correlates and evaluated the findings at a corrected threshold. We performed mediation analyses to examine the inter-relationships between win/loss responses, alcohol misuse, and

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9775947 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature