The Nature of Functional Features of Different Classes of G-Protein-Coupled Receptors.

ABSTRACT: G-protein-coupled receptors (GPCRs) are a critical family in the human proteome and are involved in various physiological processes. They are also the most important drug target, with approximately 30% of approved drugs acting on such receptors. The members of the family are divided into six classes based on their structural and functional characteristics. Understanding their structural-functional relationships will benefit us in future drug development. In this article, we investigate the features of protein function, structure, and energy that describe the dynamics of the GPCR activation process between different families. GPCRs straddle the cell membrane and transduce signals from outside the membrane into the cell. During the process, the conformational change in GPCRs that is activate

SUBMITTER: An K 

PROVIDER: S-EPMC9775959 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature