Non-Invasive Pulsatile Shear Stress Modifies Endothelial Activation; A Narrative Review.

ABSTRACT: The monolayer of cells that line both the heart and the entire vasculature is the endothelial cell (EC). These cells respond to external and internal signals, producing a wide array of primary or secondary messengers involved in coagulation, vascular tone, inflammation, and cell-to-cell signaling. Endothelial cell activation is the process by which EC changes from a quiescent cell phenotype, which maintains cellular integrity, antithrombotic, and anti-inflammatory properties, to a phenotype that is prothrombotic, pro-inflammatory, and permeable, in addition to repair and leukocyte trafficking at the site of injury or infection. Pathological activation of EC leads to increased vascular permeability, thrombosis, and an uncontrolled inflammatory response that leads to endothelial dysfunction.

SUBMITTER: Adams JA 

PROVIDER: S-EPMC9775985 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature