Activation of OSM-STAT3 Epigenetically Regulates Tumor-Promoting Transcriptional Programs in Cervical Cancer

ABSTRACT:

Simple Summary

Oncostatin M (OSM) induces Signal Transducer and Transcription 3 (STAT3) activation, exacerbating cervical cancer. The molecular mechanism by which the OSM-STAT3 axis regulates tumor-progression-related genes in cervical cancer is not well understood. Our transcriptomic and epigenomic analysis showed that OSM-induced hypoxia, wound healing, and angiogenesis genes were significantly inhibited by SD-36, the STAT3-selective degrader. Open chromatin regions of the genes that were OSM-STAT3-regulated were consistently enriched for STAT3 binding motifs. Higher levels of OSM-regulated genes’ expression were significantly linked to a poor prognosis in patients with cervical cancer. These findings show that the OSM-STAT3 signaling pathway regulates important transcriptomic p

SUBMITTER: Noh J 

PROVIDER: S-EPMC9775986 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature