Glial Contributions to Lafora Disease: A Systematic Review.

ABSTRACT:

Background

Lafora disease (LD) is a neurodegenerative condition characterized by the accumulation of polyglucosan bodies (PBs) throughout the brain. Alongside metabolic and molecular alterations, neuroinflammation has emerged as another key histopathological feature of LD.

Methods

To investigate the role of astrocytes and microglia in LD, we performed a systematic review according to the PRISMA statement. PubMed, Scopus, and Web-of-Science database searches were performed independently by two reviewers.

Results

Thirty-five studies analyzing the relationship of astrocytes and microglia with LD and/or the effects of anti-inflammatory treatments in LD animal models were identified and included in the review. Although LD has long been dominated by a neuronocentric view, a

SUBMITTER: Della Vecchia S 

PROVIDER: S-EPMC9776290 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature