CpG Site-Based Signature Predicts Survival of Colorectal Cancer.

ABSTRACT:

Background

A critical unmet medical need in clinical management of colorectal cancer (CRC) pivots around lack of noninvasive and or minimally invasive techniques for early diagnosis and prognostic prediction of clinical outcomes. Because DNA methylation can capture the regulatory landscape of tumors and can be measured in body fluids, it provides unparalleled opportunities for the discovery of early diagnostic and prognostics markers predictive of clinical outcomes. Here we investigated use of DNA methylation for the discovery of potential clinically actionable diagnostic and prognostic markers for predicting survival in CRC.

Methods

We analyzed DNA methylation patterns between tumor and control samples to discover signatures of CpG sites and genes associated with CRC and pr

SUBMITTER: Wu J 

PROVIDER: S-EPMC9776399 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature