Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer.

ABSTRACT: Cancer progression is supported by the cross-talk between tumor cells and the surrounding stroma. In this context, senescent cells in the tumor microenvironment contribute to the development of a pro-inflammatory milieu and the acquisition of aggressive traits by cancer cells. Anticancer treatments induce cellular senescence (therapy-induced senescence, TIS) in both tumor and non-cancerous cells, contributing to many detrimental side effects of therapies. Thus, we focused on the effects of chemotherapy on the stromal compartment of prostate and ovarian cancer. We demonstrated that anticancer chemotherapeutics, regardless of their specific mechanism of action, promote a senescent phenotype in stromal fibroblasts, resulting in metabolic alterations and secretion of paracrine factors, sustain

SUBMITTER: Pardella E 

PROVIDER: S-EPMC9776582 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature