Aspirin Inhibition of Prostaglandin Synthesis Impairs Mosquito Egg Development.

ABSTRACT: Several endocrine signals mediate mosquito egg development, including 20-hydroxyecdysone (20E). This study reports on prostaglandin E₂ (PGE₂) as an additional, but core, mediator of oogenesis in a human disease-vectoring mosquito, Aedes albopictus. Injection of aspirin (an inhibitor of cyclooxygenase (COX)) after blood-feeding (BF) inhibited oogenesis by preventing nurse cell dumping into a growing oocyte. The inhibitory effect was rescued by PGE₂ addition. PGE₂ was found to be rich in nurse cells and follicular epithelium after BF. RNA interference (RNAi) treatments of PG biosynthetic genes, including PLA₂ and two COX-like peroxidases, prevented egg development. Interestingly, 20E treatment significantly increased the expressio

SUBMITTER: Choi D 

PROVIDER: S-EPMC9776805 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature