The Tumor Microenvironment of Hepatocellular Carcinoma: Untying an Intricate Immunological Network.

ABSTRACT: HCC, the most prevalent form of primary liver cancer, is prototypically an inflammation-driven cancer developing after years of inflammatory insults. Consequently, the hepatic microenvironment is a site of complex immunological activities. Moreover, the tolerogenic nature of the liver can act as a barrier to anti-tumor immunity, fostering cancer progression and resistance to immunotherapies based on immune checkpoint inhibitors (ICB). In addition to being a site of primary carcinogenesis, many cancer types have high tropism for the liver, and patients diagnosed with liver metastasis have a dismal prognosis. Therefore, understanding the immunological networks characterizing the tumor microenvironment (TME) of HCC will deepen our understanding of liver immunity, and it will underpin the domi

SUBMITTER: Volponi C 

PROVIDER: S-EPMC9776867 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature