Burden and Risk Factors of Brain Metastases in Melanoma: A Systematic Literature Review.

ABSTRACT: Melanoma can frequently metastasize to the brain with severe consequences. However, variation of melanoma brain metastases (MBM) development among populations is not well studied, and underlying mechanisms and risk factors for MBM development are not consistently documented. We conducted a systematic literature review (SLR) including a total of 39 articles to evaluate the proportion of melanoma patients who are diagnosed with, or develop, brain metastases, and summarize the risk factors of MBM. The average proportion of MBM was calculated and weighted by the sample size of each study. Meta-analyses were conducted for the selected risk factors using a random-effects model. The proportion of MBM at diagnosis was 33% (975 with MBM out of 2948 patients) among patients with cutaneous melanoma (

SUBMITTER: Tan XL 

PROVIDER: S-EPMC9777047 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature