Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review.

ABSTRACT: OFCs (orofacial clefts) are among the most frequent congenital defects, but their etiology has yet to be clarified. OFCs affect different structures and functions with social, psychological and economic implications in children and their families. Identifying modifiable risk factors is mandatory to prevent the occurrence of non-syndromic OFCs (NSOFCs). PubMed, Cochrane Library, Scopus and Web of Science were searched from 1 January 2012 to 25 May 2022 and a total of 7668 publications were identified. Studies focusing on the risk factors of NSOFCs were selected, leading to 62 case-control and randomized clinical trials. Risk factors were categorized into non-modifiable and modifiable. The first group includes genetic polymorphisms, gender of the newborn, ethnicity, and familiarity. Within t

SUBMITTER: Inchingolo AM 

PROVIDER: S-EPMC9777067 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature